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This approval follows the December 2025 approval of Novo Nordisks once-daily oral Wegovy pill (semaglutide 25 mg), the first oral GLP-1 approved for chronic weight management in adults

10.1073/pnas.85.14.5171 Proc Natl Acad Sci USA

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Reducing conditions (trace metals, UV light, repeated oxygen exposure from freeze-thaw cycling) can disrupt these disulfide bonds, unfolding the peptide