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Pancreas GLP-1 and GIP stimulate insulin secretion GLP-1 suppresses glucagon secretion during hyperglycemia GIP suppresses glucagon secretion during hyperglycemia and stimulates secretion during euglycemia and hypoglycemia Brain GLP-1 and GIP suppress hunger Stomach GLP-1 slows gastric emptying Fat tissue GIP increases fatty acid and glucose uptake by fat tissue [1,2,3] Tirzepatide Tirzepatide is a dual GLP-1 / GIP receptor agonist that mimics the actions of GLP-1 and GIP

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Current status of glucagon-like peptide-1 receptor agonists in metabolic dysfunction-associated steatotic liver disease: a clinical perspective

The effects of gut-derived GLP-1 secretion are considered to be more significant in preventing weight gain rather than directly inducing weight loss, based on findings from animal studies on GLP-1 releasers including gastrointestinal distention [53] and d-allulose [54]

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Abstract Growth hormone (GH) and its mediator insulin-like growth factor-1 (IGF-1) have manifold effects on the kidneys