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As of 2024, it is in Phase 3 trials for both obesity and type 2 diabetes

Exenatide (shown on the right, PDB 7LLL), which was the first GLP-1 receptor agonist approved by the FDA, shares just over 50% sequence identity with GLP-1, but has a similar structure and is able to activate the GLP-1 receptor, while avoiding rapid proteolytic degradation

Consultation and Prescription: Working with a Healthcare Provider It is important to keep in mind that the specifics may change based on your location and the healthcare system you are using

Stability Observations in Research Settings Labs report reduced peptide activity when solutions are repeatedly warmed or exposed to light

Additionally, we excluded cases with missing data or those lost to follow-up to maintain data completeness

Summary: Rybelsus is the first oral GLP-1 receptor agonist (semaglutide) licensed in the UK for treating type 2 diabetes in adults, offering a convenient tablet alternative to injectable GLP-1 therapies