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Safety Concerns and Contraindications Despite favorable preclinical profiles, theoretically plausible adverse effects exist based on BPC-157s mechanisms

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29,33,38 The potential for adverse events due to osmotic laxatives is higher in patients with preexisting renal disease or heart failure

Acknowledgements This work was partially funded by the Italian Ministry of Education (MIUR, Grant to GS) and by Sigma Tau Industrie Farmaceutiche Riunite (Grant to GR)