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Additional Resources: MYTH #6: You can stop GLP-1 medication after reaching your goal weight. FACT For most patients, stopping GLP-1s leads to: Increased hunger Elevated cravings Regained body fat Worsening insulin resistance Data suggests that on average, patients regained two-thirds of the weight lost after discontinuation (JAMA Network Open analysis of GLP-1 discontinuation)

The main enzymatic product, 6-hydroxymelatonin (6-OHM), is generated in the liver by cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP2C19) and is further converted to 6-hydroxymelatonin sulfate for urinary excretion [21]

Knop FK, Bronden A, Vilsboll T

J Biol Chem 275(11):75057514

Berberine may contribute to improved heart health by lowering cholesterol and triglyceride levels, which could potentially reduce the risk of heart disease