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Our independent findings demonstrate that PDHA1, a metabolic gatekeeper in PCa that channels pyruvate into the TCA cycle to generate acetyl-CoA, elevates intracellular acetyl-CoA to enhance H3K27ac and thereby upregulates solute carrier family 7 member 11 (SLC7A11), increasing cysteine uptake and glutathione (GSH) synthesis

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They recognize the antigens through binding between TCR and MHC class I associated with antigen peptide

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10.1016/j.ijcard.2012.01.013 Int