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Benefits of early pharmacologic augmentation Early introduction of anti-obesity medications (AOMs) for GLP-1 agonist non-responders offers several advantages: Enhanced weight reduction : Incorporating phentermine just one month after beginning behavioral therapy more than doubled weight loss compared to placebo (5.9% vs

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GSDMD-knockdown (GSDMD-KD) THP-1 cells were established and western blot results showed that the expression of GSDMD-FL, GSDMD-N, IL-1, and IL-18 were significantly downregulated in GSDMD-KD THP-1 cells (Fig