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The systemic nature and widespread prevalence of MASH have led to significant economic burdens, with costs reaching $222.6 billion in the USA in 2017 and up to 19.5 billion in Europe, encompassing both direct (medical care, diagnostic procedures, drugs, hospitalization) and indirect costs (loss of productivity, reduced quality of life, morbidity, and mortality) [11, 12]

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doi: 10.1038/npp.2011.220 75 HaroonE.MillerA

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Understanding these layered mechanisms explains why semaglutide effects unfold over weeks rather than days