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L-carnitine also helps with the oxidation (burning) of pyruvate and branched chain amino acids in the energy cycle (Bremer 1983) It also prevents the build-up of fatty complexes within cells, which can damage muscle cell membranes (Stumpf 1985)

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In summary, combining structural data from cryo-EM, receptor mutagenesis, pharmacological assays and MD simulations advances our understanding of peptide agonist engagement with the GLP-1R