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For many, these physiological benefits outweigh any medication-related suppression, leading to increased libido

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This review helps ensure that the medication can be prescribed responsibly across varied patient populations

The underlying mechanism involves the modulation of gutrenal axis through the optimization of microbial composition, promoting the development of beneficial bacteria while inhibiting harmful microbes

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Over 250 patients underwent metabolomics and lipidomic investigations, which revealed that unlike the baseline and placebo, tirzepatide, taken over 26 weeks, significantly impacted a group of lipids and metabolites like 3-hydroxybutyrate reduced branched-chain ketoacids (BCKA), branched-chain amino acids (BCAA), and direct catabolic products linked with obesity and insulin resistance