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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Amylase Test Lipase Test Vitamin Tests: These are essential for detecting nutrient deficiencies, as GLP-1 medications may suppress appetite and reduce overall nutrient intake 13

[11] Serious but uncommon events include immediate-type hypersensitivity with urticaria, bronchospasm, or anaphylaxis, and delayed eosinophilic myositis

Physical Function Aging is associated with declining physical function manifested as lower gait speed, muscle strength, and exercise capacity

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