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Chronic kidney disease in liver transplant candidates: a rising burden impacting postliver transplant outcomes

It is important to separate these myths from the clinical reality

In a head-to-head trial in adults with obesity or overweight without diabetes, tirzepatide, the active ingredient in Mounjaro and Zepbound led to greater average weight loss than semaglutide over 72 weeks.However, there are various factors to consider when determining which medication is the best fit for an individual's unique needs including cost and insurance coverage, overall health, side effects, and how well the medication aligns with one's lifestyle and goals

doi:10.1053/j.gastro.2008.07.075 131

More importantly, these modified GLP-1 analogues have shown hypoglycemic [185, 186] and cardiovascular protective effects [180, 183] in different animal models

Further mechanistic studies are needed to test these hypotheses and explore potential mechanisms of action of GIP analogues, such as Tirzepatide tested here, for reducing alcohol intake