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We are conserving calories, and were conserving the need to get out of our cave and to go hunt for food

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Pretreatment of capsaicin reduces the levels of pro-inflammatory cytokines IL-1 and IL-6 in brain tissue stimulated by ibotenate, and inhibits the activity of brain mast cells in a dose-dependent manner [193]

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Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult