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doi:10.1001/jamanetworkopen.2024.47644 Milushewa P, Mitreva Y, Chakarova N, Tankova T, Naseva E, Petkova V

Relative to comparators, the risk for any of the commonly used cardiovascular end points was estimated to be below 1.0, and for both MACE-4 and MACE-3 (myocardial infarction, stroke, and all-cause death), the upper bounds of the confidence interval calculated around the hazard ratio were decidedly 8.5 %

doi: 10.1210/clinem/dgaa839 14 LinH-TWuM-HTsaiL-CChenT-SOuH-T

However, many Type 2 diabetics will not achieve sufficient control of their blood sugar on metformin alone and will be placed on one or more additional therapies, as outlined in the previously mentioned treatment guidelines