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Since MOTS-c activates many of the same downstream pathways triggered by physical activity, including AMPK signaling, increasing mitochondrial efficiency, and improving fatty acid oxidation, MOTS-c has also been called an exercise mimetic in scientific literature

& Gupta, U

None of these compounds has undergone a Phase 3 randomized controlled trial in humans that would support an FDA drug approval claim

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Animals treated with 5-amino-1MQ showed no signs of toxicity, behavioral changes, or adverse effects at therapeutically effective doses