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Piceatannol (PCN), a SIRT1 activator, was found to increase mitotic biogenesis and mitophagy via the SIRT1-PGC-1-NRF2-TFAM and SIRT1-PINK1-Parkin axes in the STZ-induced SD rat and HG-induced murine Neuro2a cell models, thus exerting some neuroprotective protective effects [168]

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