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4.3 Neurodegenerative diseases Since individuals with DS are prone to elevated levels of oxidative stress at an early age and consequent accumulation of ROS, which are cytotoxic byproducts of normal mitochondrial metabolism, there is an insufficient defense of endogenous antioxidants

doi: 10.1038/s41581-019-0145-4 145

STI2030-Major Project 2021ZD0203400 (Q.T.Z.)

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Some researchers prefer morning administration, reasoning that any transient nausea will occur during active hours when it is easier to manage