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The peptide mimetic DPP-4 inhibitors including vildagliptin, saxagliptin and teneligliptin, were identified by peptide-based substrate substitution experiments, while the non-peptide mimetic group such as sitagliptin, alogliptin and linagliptin, were derived from the inhibitor and initially found in random screening

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If 2.4 mg is not tolerated, the documented fallback is to hold at the highest tolerated step (commonly 1.7 mg) rather than push through severe GI effects