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(PubMed) Labunskyy VM, Hatfield DL, Gladyshev VN

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The connection between metformin and AMPK is historically known

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In addition, it was also reported that the presence of distinct metabolites such as the Asn-Pro-Arg, deoxyuridine, DG(14:1/22:6), FFA(18:2), Glu-Met, Glycyl-Tryptophan, linolenic acid, hyroxyhexadecanoic acid, indole-3-lactic acid, isoleucine, Leu-Glu, MG(18:0), norvaline, oxindole, oxohexadecanoic acid, PA (8:0/13:0), PE (18:4), pentadecanoic acid, tryptophan, Tyr-Leu-Arg, and uridine was markedly associated with pharmacodynamic assessment indices such as total flux and tumour inhibition rate [192]

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