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The cryo-EM maps allowed us to build an unambiguous model for most regions of the complexes except for the flexible -helical domain (AHD) of G and the stalk between transmembrane helices 1 (TM1) and ECD, which were poorly resolved in most cryo-EM structures of GPCRG s complex (Supplementary Fig

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Similar content being viewed by others 1 Introduction Cancer cachexia is a paraneoplastic syndrome present in 80% of terminally ill patients [13] and is markedly associated with adverse prognosis and shortened survival time [4, 5]

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42(6): 60812 Zeisel S, Da Costa K, Ox J

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