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Other treatments, such as microneedling, laser therapy, or chemical peels, can help improve the texture of acne scars and skin tone

This is the strongest peer-reviewed human evidence in the T4 family, although the formulation tested was full-length T4, not the TB-500 fragment

Care Cancer 15 , 11131114 (2007)

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However, combining compounds increases complexity and requires careful oversight

Third, the discovery that MOTS-c also plays roles in immune regulation, particularly in suppressing innate immune overactivation, has opened research directions in inflammation-driven aging, autoimmunity, and potentially long-term sequelae of infections