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Data: Jastreboff et al., NEJM 2023 (Phase 2)

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What is KPV

Chromatin immunoprecipitation (ChIP) The SIRT1 promoter sequence was obtained from the UCSC Genome Browser ( and the potential binding relationship of HOXA2 to the SIRT1 promoter was predicted by the JASPAR tool

This state may be secondary to a persisting stressor, such as a redox imbalance (251), persistent infection (201, 251), injury (201), insufficient nutrients (201), cold temperatures (201), or it could be due to a defect in the switch that turns off this protective state (251)

doi: 10.1007/s00018-019-03351-7 43 LiDJiHNiuXYinLWangYGuYet al