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This characteristic makes B12 one of the safer vitamins to supplement, with no established upper tolerable intake level set by UK health authorities

Side effects of B12 supplementation Vitamin B12 is a water-soluble vitamin, which means excess amounts are excreted through the urine

The most common neurological manifestation is subacute combined degeneration of the spinal cord and peripheral sensory neuropathy, while epilepsy is a rare manifestation in cases of vitamin B12 deficiency [84]

However, the repeated or continuous inflammatory and demyelinating processes plus endogenous attempts for remyelination and repair increase vitamin B12 consumption and may lead to its deficiency