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Aggrecan is a critical proteoglycan for maintaining disc hydration and shock-absorbing capacity
Recently, the expression of the GLP-1 receptor has been reported in the knee joint of rat cartilage 35 and in chondrocytes from mouse tracheal cartilage 36 , but has never been described in OA patients or in mouse articular cartilage and synovial membrane
Cost Comparison According to typical pricing, prescription GLP-1 medications without insurance cost $900-$1,500 per month, though insurance coverage can reduce copays to $25-$50 monthly when covered for diabetes management
Domestic synthesis under cGMP conditions implies standardized equipment calibration, environmental controls, documented procedures, and quality management systems
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