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A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss

Association of low molecular weight plasma aminothiols with the severity of coronavirus disease-2019

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One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle

Vasconcelos et al., 2016