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Both work completely differently

5-Amino-1MQ Synonyms / Designations: 5-Amino-1-methylquinolinium, 5-Amino-1-MQ, NNMT inhibitor analog CAS Number: 42464-96-0 Molecular Formula: C10H11N2+ (monocationic quaternary ammonium) Molecular Weight: ~159.21 g/mol Purity: 98.5 % (HPLC, typical) Appearance: Off-white to pale yellow crystalline powder Pack Size: 10 mg (total) Storage: Desiccated, protected from light, stored at 20 C Solubility: Soluble in water, dilute acids

Researchers tested the selectivity of the BBB in cats

Xie TY, Ngo ST, Veldhuis JD, Jeffery PL, Chopin LK, Tschop M, Waters MJ, Tolle V, Epelbaum J, Chen C, Steyn FJ

Research in cell culture and rodent models consistently demonstrates that MOTS-c accelerates this translocation independently of insulin, offering a distinct and additive mechanism to insulin sensitizers like Metformin [1]