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Accordingly, the list of molecules which have been shown unequivocally to be physiological substrates of DPP-4 is short ( GLP-1 and GIP With regard to metabolic effects, the best characterized DPP-4 substrates are the two incretin hormones, GLP-1, and glucose-dependent insulinotropic polypeptide (GIP)

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Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]

Characteristics of GLP-1RAs GLP-1 receptor agonists (GLP-1RAs) have transformed the management of type 2 diabetes and obesity