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If soreness continues across multiple properly rotated sites, reduce injection volume to 0.51ml and consider splitting the weekly dose into two smaller injections rather than one large bolus

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The study also demonstrated the protective effect of exenatide on islet-cell function during GCs therapy, providing early evidence for using GLP-1 RAs to counteract the diabetogenic effects of GCs (34)

1ah (vehicle (isotonic saline), n = 10 mice, 100 nmol kg 1 MK-801 n = 10 mice, 100 nmol kg 1 GLP-1 n = 10 mice, 100 nmol kg 1 GLP-1MK-801 n = 10 mice)

Morning or early afternoon is most common