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Consistent with these observations, patients included in the studies analyzed in this systematic review frequently reported significant cardiometabolic benefits in addition to BW loss

Thiamine and thiamine diphosphate (TDP) concentrations are reduced by 20% in cancer patients blood, transketolase activity is reduced by 20%, and the TDP impact is reduced by 542% (86) ( Table 2 )

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Together, they are commonly evaluated in preclinical and in vitro studies examining peptide interactions and hormone signaling pathways