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The microneedling creates micro-channels that deliver copper peptides directly to the dermal papilla the exact target cells identified in Pyo et al.'s 2007 work

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38,39 However, the Wnt/-catenin signalling pathway is not only positively activated by the above factors but also inhibited by many negative feedback regulators, such as Notum, Tiki, DKKs, Wise/SOST, IGFBP-4, sFRPs, WIF1, and ZNRF3/RNF43

[6] Smeyne M, Smeyne RJ

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