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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Teenage patients had higher proportion of hypertension (34% vs 6.3%), atrial fibrillation (12.5% vs 1.2%) and previous stroke (16.9% vs 9%) than young adults (P 160/100) and new (within 3 months) anti-hypertensive medication

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This coordination stabilizes copper in a biologically available form, allowing it to interact with cellular targets without generating oxidative stress. The copper ion also acts as a catalytic cofactor in enzymes involved in collagen cross-linking, antioxidant defense, and wound remodeling