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This study found that participants regained a significant portion of lost weight after discontinuing semaglutide: Rubino D et al., Discontinuation of GLP-1 Receptor Agonist Therapy and Weight Regain, Frontiers in Endocrinology , 2021

Always consult a qualified healthcare provider before starting or adjusting any medication

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This might be due to the fact that GLP-1RAs have a delaying effect on gastrointestinal emptying, which could exacerbate gastrointestinal disorders or predispose to the development of prior gastrointestinal disorders

GLP-1 receptor agonists are a popular class of medications used to help manage type 2 diabetes and, more recently, support weight loss