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All GLP-1 receptor agonists cause similar modest heart rate increases of approximately 24 beats per minute on average, including liraglutide, semaglutide, dulaglutide, and tirzepatide

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A clinically significant interaction exists between tirzepatide and oral contraceptives, with FDA labeling advising use of non-oral or backup contraception for 4 weeks after initiation and each dose increase

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