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Overall, melatonin's ability to affect multiple pathways involved in the pathophysiology of FM makes it a promising adjunctive treatment for this chronic pain syndrome [66, 67]

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The authors proposed multiple potential mechanisms including interactions with opioid, GABAergic, and monoaminergic systems, establishing the conceptual framework for subsequent mechanistic research into DSIP's neurophysiological actions

They do not establish that combining GHK-Cu with three unrelated experimental peptides produces a predictable clinical effect

There's evidence it upregulates growth factor receptors, modulates nitric oxide, and influences the way fibroblasts (the cells that lay down collagen) organize and migrate

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