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The intravenous form is preferred in patients with severe toxicity, altered mental status, or significant vomiting, whereas the oral formulation remains an option when intravenous access is not feasible
RCTs of liraglutide in PCOS Liraglutide is a long-acting human GLP-1 RA currently approved for weight loss management in patients with obesity [47]
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When higher doses (3.0 mg and 4.5 mg) were tested, weight loss increased to 4.1 kg (9 lbs) and 4.7 kg (10.4 lbs) over nine months
The proposed mechanism involves controlling glutamate release in the synaptic cleft, modulating NMDA receptor stimulation, affecting excitatory amino acid transporter (EAAT)-mediated reuptake, and maintaining the glutamate/glutamine cycle within astrocytes
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