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Notably, compared to the use of GIPR antibodies alone or control antibody-GLP-1 conjugates, GIPR-Ab/GLP-1 exhibits a more potent weight-reducing effect, suggesting a synergistic interaction between the two targeting mechanisms

(2) the bi-functional catalase-peroxidases, members of a protein family predominantly present among eubacteria and archaea with only two evolutionary branches found in eukaryotic organisms

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Unusually, it also targets glucose-dependent insulinotropic polypeptide (GIP) receptors, which are also involved in managing insulin release, fat storage, metabolism, and appetite

References Adalatkhah H., Pourfarzi F., Sadeghi-Bazargani H

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