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A peptide discussed for tissue growth or regeneration should not be assumed harmless, especially when long-term human exposure, tissue selectivity, and dose-response are not established [15] [20]

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HershmanDLUngerJMCrewKDMinasianLMAwadDMoinpourCMet al

The study, which ended prematurely due to a higher mortality rate in the intensive treatment group, failed to report significant reduction in major cardiovascular events, giving a notion that intensive therapy was associated with significant harm in high risk patients [6]