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In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

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doi: 10.1017/S109285292100002X

A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

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