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c Performed significantly more poorly than comparator.

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Tirzepatide is aprescription-only injectable therapy that engages both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor pathways involved in appetite signaling, nutrient sensing, and metabolic regulation

Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing

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