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Adverse Reactions Occurring at an Incidence of 2% or More and At Least Twice Placebo Among VYVANSE Treated Patients with BED in Clinical Trials Adverse reactions reported in the pooled controlled trials in adult patients (Study 11 and 12) treated with VYVANSE or placebo are presented in Table 4 below

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In particular, rapid trimethylation of histone H3 at lysine 4 (H3K4me3) was observed in mouse livers after weekly 6-hour light-dark phase advances 223