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Fento-1 exhibits a distinct chemotype to investigate ferroptosis and provides a conceptual framework to target DTP cancer cells 38

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Aleksandrova, K., Koelman, L., & Rodrigues, C

2,3-Bisphosphoglycerate (2,3-BPG) is an intermediate metabolite present in high concentrations in RBCs (approximately 5 mM) and is the principal allosteric effector for hemoglobin (that is present at almost the same concentration as a tetramer), decreasing its affinity for oxygen

Coupled with the absence of clinical outcome measures and human clinical trial evidence, their direct clinical translation is restricted, highlighting an urgent need for more clinically relevant studies to optimize intervention strategies and clarify the actual therapeutic value of iron chelators in DR patients