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NICE Guidelines on Using DPP-4 Inhibitors in Type 2 Diabetes NICE NG28 recommends DPP-4 inhibitors as second- or third-line therapy alongside metformin, particularly when hypoglycaemia risk or weight gain is a concern, but prioritises SGLT-2 inhibitors in patients with cardiovascular disease or chronic kidney disease

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In short, GLP-1 receptor agonists now occupy a leading position among the worlds best-selling medicines , reflecting unprecedented demand for these new diabetes and obesity treatments

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