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However, despite adequate protocols, methodological flaws such as lack of randomization, concealment of allocation, lack of blinded outcome evaluation, and high heterogeneity in the doses used in supplementation, as well as among the included studies, can compromise the level of evidence generated in this systematic review

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Without insurance coverage, these medications can be expensive, though manufacturer savings cards (coupons) are often available for eligible patients

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Jill Furman, FDLI Enforcement Conference (December 2025)