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This pattern, often called obesity-related hypogonadism, can lead to symptoms like fatigue, low libido, and infertility

Evidence comes from large-scale studies such as the SCALE and LEAD trials for liraglutide, the STEP 18 program for semaglutide, the SURMOUNT 14 trials for tirzepatide, AWARD-11 for dulaglutide, and DURATION-1 for exenatide (Table 3)