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5 So that begs the answer to the question, is GLP-1 microdosing an option to maintain a healthy weight in perimenopause? While GLP-1 popularity in brands like Ozempic has surged, with benefits being tied to the FDA-recommended dosages, researchers have documented growing interest in GLP-1 microdosing a term that may describe two distinct practices: 6 Standard, physician-guided dose adjustments Off-label use of GLP-1 drugs at doses lower than those the FDA recommends The idea, publications explain, is for individuals to reap the benefits of GLP-1s with reduced side effects, which may include: 7 Nausea Vomiting Diarrhea Headache Experts believe the concept of GLP-1 microdosing may have stemmed from obesity drug shortages in 2021 and 2022

Yankelevitch-Yahav R, Franko M, Huly A, Doron R (2015) The forced swim test as a model of depressive-like behavior

The specific dose-to-clicks number depends on how much drug the pen contains

Neuroinflammation as a driver of depression and its response to low-dose naltrexone

For instance, ketogenic diets or ketone supplements alter the production of GLP-1 (Wallenius et al., 2020)

The medications' effects on appetite regulation and satiety might also play an indirect role, as some individuals report that reduced overall appetite extends to diminished desire for alcohol