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The most consistent safety pattern in published trial reports is gastrointestinal

Following deduplication, titles and abstracts were screened, and full texts were reviewed

Treatment must be provided by specialist weight management services and is typically reviewed after fixed time periods

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Copper is essential for enzymes like lysyl oxidase (which cross-links collagen and elastin) and superoxide dismutase (an antioxidant)

This leads to an unstable breathing pattern with episodes of hypocapnia that reduce respiratory drive and may facilitate airway collapse [11]