One important finding from clinical trials is that gastrointestinal side effects like nausea, vomiting, diarrhea are highly related to the medication dose and the rate the dose is increased
Temperature changes, chills, hair shedding, sulfur-tasting burps, and low mood appear in user reports but were measured thinly or not at all in trials
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Most participants in the STEP trials reported that gastrointestinal symptoms resolved or became minimal within 4 to 8 weeks of maintaining a stable dose
7 It has been shown that GLP-1 receptors in the choroid plexus alter Na+/K+-ATPase activity, which directly influences CSF production and may reduce ICP without exclusively depending on weight reduction