Additionally, high ChaC1 expression increases tumor cell sensitivity to anti-tumor drugs by inducing ER stress and ferroptosis (65,69,138)
For example, hypervitaminosis A can be caused by taking one large dose of over 200 mg of vitamin A, or chronic use of more than 10 times the recommended daily intake ( Vitamin A toxicity may lead to serious complications, such as increased spinal fluid pressure, coma, and potentially fatal organ damage ( Additionally, taking megadoses of vitamin D more than 50,000 IU daily over long periods can lead to high blood levels of calcium (hypercalcemia), which can lead to death ( Overdosing on other vitamins can likewise cause potentially fatal side effects, such as liver damage
Baseline aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin before starting IV glutathione, with a repeat panel at 8 to 12 weeks, is a reasonable precaution
however, clinical trials are currently lacking (Schepici et al., 2020
J Clin Endocrinol Metab (2007) 92(4):12638
J Arrhythm 2020;37:1-10
