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it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia

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Some GLP-1 agonists, like semaglutide and liraglutide, are also approved by the Food and Drug Administration (FDA) for treating obesity