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Starting weight, dose escalation speed, and lifestyle adherence create variation, but clinical experience shows this range is typical for the majority of users beginning at 0.25 mg and advancing to 1.0 mg or higher

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The association of pruritus with cholestasis suggests that it is caused by a substance normally excreted in bile, and the efficacy of cholestyramine in providing relief from pruritus strongly suggests that the pruritogenic factor has an enterohepatic circulation